食品安全科学研究所

Enable discovering in food safety

科研方向:
 
 
科研成果:
1、代表性论文
    • Hua Kuang,† Wei Ma,† Liguang Xu, Libing Wang,* And Chuanlai Xu*, Nanoscale Superstructures Assembled by Polymerase Chain Reaction (PCR): Programmable Construction, Structural Diversity, and Emerging Applications. Accounts of Chemical Research. 2013, DIO: 10.1021/ar300206m. (2013IF=20.833)

 

    • Liguang Xu, Wei Ma, Libing Wang, Chuanlai Xu, Hua Kuang and Nicholas A. Kotov, Nanoparticle assemblies: dimensional transformation of nanomaterials and scalability, Chem. Soc. Rev., 2013, 42, 3114-3126. (2013IF=24.892)

 

    • Yuan Zhao, Liguang Xu, Luis M. Liz-Marzan, Hua Kuang, Wei Ma, F. Javier García de Abajo, Nicholas A. Kotov, Libing Wang, and Chuanlai Xu*. Alternating Plasmonic Nanoparticle Heterochains Made by Polymerase Chain Reaction and Their Optical Properties. J. Phys. Chem. Lett. 2013, 4, 641−647 (2013IF=6.585).

 

    • Hua Kuang, Zhe Li, Chifang Peng, Liqiang Liu, Liguang Xu, Yingyue Zhu, Wei Chen, Ruirui Qiao & Chuanlai Xu*. Metabonomics approaches and the potential application in foodsafety evaluation. Critical Reviews in Food Science and Nutrition. 2011, DOI: 10.1080/10408398.2010.508345. (2010IF=3.25)

 

    • Liguang Xu, Yingyue Zhu, Wei Ma, Wei Chen, Liqiang Liu, Hua Kuang, Libing Wang, Chuanlai Xu*. Gold Nanorod Ensembles as Artificial Molecules for Applications in Sensor, J. Mater. Chem., 2011, DOI: 10.1039/C1JM11905B. (2010IF=5.099)

 

    • Liguang Xu, Yingyue Zhu, Wei Ma, Hua Kuang, Liqiang Liu, libing wang, and Chuanlai Xu*. Sensitive and Specific DNA Detection Based on Nicking Endonuclease-Assisted Fluorescence Resonance Energy Transfer Amplification. J. Phys. Chem. C, Publication Date (Web): 15 July 2011. (2010IF=4.52)

 

    • Yingyue Zhu, Liguang Xu, Wei Ma, Wei Chen, Wenjing Yan, Hua Kuang, Libing Wang∗, Chuanlai Xu. G-quadruplex DNAzyme-based microcystin-LR (toxin) determination by a novel immunosensor. Biosensors and Bioelectronics 26 (2011) 4393-4398. (2010IF=5.361)

 

    • Yingyue Zhu, Changlong Qu, Hua Kuang, Liguang Xu, Liqiang Liu, Wei Chen, Yufei Hua, Libing Wang, Chuanlai Xu*. Simple, rapid and sensitive detection of antibiotics based on the side-by-side assembly of gold nanorod probes. Biosensors and Bioelectronics 2011, 26(11):4387-4392. (2010IF=5.361)

 

    • Zhuokun Li, Feng Xue, Liguang Xu, Chifang Peng, Hua Kuang*, Tao Ding, Chuanlai Xu, Chongyu Sheng, and Yuxia Gong. Simultaneous Determination of Nine Types of Phthalate Residues in Commercial Milk Products Using HPLC–ESI-MS–MS. Journal of Chromatographic Science, 2011, 49: 338-343. (2010IF=1.078)

 

    • Liguang Xu, Yingyue Zhu, Wei Ma, Wei Chen, Liqiang Liu, Hua Kuang, Libing Wang and Chuanlai Xu*. New Synthesis Strategy for DNA Functional Gold Nanoparticles. J. Phys. Chem. C. 2011, 115: 3243-3249. (2010IF=4.52)

 

    • LibingWang, Wenwei Ma,Wei Chen, Liqiang Liu, Wei Ma, Yingyue Zhu, Liguang Xu, Hua Kuang*, Chuanlai Xu. An aptamer-based chromatographic strip assay for sensitive toxin semi-quantitative detection. Biosensors and Bioelectronics 26 (2011) 3059–3062. (2010IF=5.361)

 

    • Hua Kuang,Wei Chen,Wenjing Yan, Liguang Xu, Yingyue Zhu, Liqiang Liu, Huaqin Chu, Chifang Peng, LibingWang, Nicholas A. Kotov, Chuanlai Xu*. Crown ether assembly of gold nanoparticles: Melamine sensor. Biosensors and Bioelectronics. 2011, 26: 2032–2037. (2010IF=5.361)

 

    • Hua Kuang, Shuge Zhao, Wei Chen, Wei Ma, Qianqian Yong, Liguang Xu, Libing Wang, Chuanlai Xu. Rapid DNA Detection by Interface PCR on Nanoparticles. Biosensors and Bioelectronics, 2011, 26: 2495–2499. (2010IF=5.361)

 

    • Sudhanshu Srivastava, Aaron Santos, Kevin Critchley, Ki-Sub Kim, Paul Podsiadlo, Kai Sun, Jaebeom Lee, Chuanlai Xu, G. Daniel Lilly, Sharon C. Glotzer* and Nicholas A. Kotov*. Light-Controlled Self-Assembly of Semiconductor Nanoparticles into Twisted Ribbons. Science. 2010, 327 (5971): 1355-1359.

 

    • Libing Wang, Wei Chen, Dinghua Xu, Bong Sup Shim, Yingyue Zhu, Fengxia Sun, Liqiang Liu, Chifang Peng, Zhengyu Jin, Chuanlai Xu*, Nicholas A. Kotov. Simple, Rapid, Sensitive, and Versatile SWNT-Paper Sensor for Environmental Toxin Detection Competitive with ELISA. Nano Letters. 2009,9(12): 4147-4152.

 

    • Wei Chen, Dinghua Xu, Liqiang Liu, Chifang Peng, Yingyue Zhu, Wei Ma, Ai Bian, Zhe Li, Yuan Yuan, Zhengyu Jin, Shuifang Zhu, Chuanlai Xu*, and Libing Wang. Ultrasensitive Detection of Trace Protein by Western Blot Based on POLY-Quantum Dot Probes. Analytical Chemistry. 2009, 81(21):9194-9198.

 

    • Libing Wang, Wei Ma, Liguang Xu, Wei Chen, Chuanlai Xu*, Nicholas A. Kotov. Nanoparticle-based environmental sensors. Materials Science and Engineering R. 2010. DOI:10.1016/j.mser.2010.06.012.

 

    • Wei Chen, Naifeng Xu, Liguang Xu, Libing Wang, Zuokun Li, Wei Ma, Yingyue Zhu, Chuanlai Xu*, Nicholas A. Kotov. Multifunctional Magnetoplasmonic Nanoparticle Assemblies for Cancer Therapy and Diagnostics. Macromolecules Rapid Communications. 2009, 31(2): 228-236.

 

    • Libing Wang, Yingyue Zhu, Liguang Xu, Wei Chen, Hua Kuang, Liqiang Liu, Ashish Agarwal, Chuanlai Xu*, Nicolas A. Kotov. Side-by-Side and End-to-End Gold Nanorod Assemblies for Environmental Toxin Sensing. Angew. Chem. Int. Ed. 2010, 49, 5472 –5475.

 

    • Bong Sup Shim, Wei Chen, Chris Doty, Chuanlai Xu*, and Nicholas A. Kotov. Smart electronic yarns and wearable fabrics for human biomonitoring made by carbon nanotube coating with polyelectrolytes. Nano Letters. 2008, 8(12): 4151-4157.

 

    • Wei Chen, Ai Bian, Ashish Agarwal, Liqiang Liu, Hebai Shen, Libing Wang, Chuanlai Xu*, Nicholas A. Kotov. Nanoparticle superstructures made by PCR: collective interactions of nanoparticles and new principle for chiral materials. Nano Letters. 2009, 9(5): 2153-2159.

 

    • Wei Chen, Chifang Peng, Zhengyue Jin, Ruirui Qiao,WuyangWang, Shuifang Zhu, Libing Wang, Qinhui Jing, Chuanlai Xu*. Ultrasensitive immunoassay of 7-aminoclonazepam in human urine based on CdTe nanoparticle bioconjugations by fabricated microfluidic chip. Biosensors and Bioelectronics. 2009, 24(7): 2051-2056.

 

    • Wei Chen, Yuan Jiang, Baoqing Ji, Changqin Zhu, Liqiang Liu, Chifang Peng, Jin M. Kim, Ruirui Qiao, Zhengyu Jin, Libing Wang, Shuifang Zhu, Chuanlai Xu*. Automated and ultrasensitive detection of methyl-3-quinoxaline-2-carboxylic acid by using gold nanoparticles probes SIA-rt-PCR. Biosensors and Bioelectronics 2009, 24: 2858-2863.

 

    • Chifang Peng, Zhuokun Li, Yinyue Zhu, Wei Chen, Yuan Yuan, Liqiang Liu, Qiusheng Li, Dinghua Xu, Ruirui Qiao, Libing Wang, Shuifang Zhu, Zhengyu Jin, Chuanlai Xu*. Simultaneous and sensitive determination of multiplex chemical residues based on multi-color quantum dot probes. Biosensors and Bioelectronics 2009, 24: 3657-3662.

 

    • Wei Ma, Wei Chen, Ruirui Qiao, Chunyan Liu, Chunhui Yang, Zhuokun Li, Dinghua Xu, Chifang Peng, Zhengyu Jin, Chuanlai Xu*, Shuifang Zhu, Libing Wang. Rapid and sensitive detection of microcystin by immunosensor based on nuclear magnetic resonance. Biosensors and Bioelectronics 2009, 25: 240-243.

 

    • Daocheng Pan, Xiaolei Wang, Z. Hong Zhou, Wei Chen, Chuanlai Xu*, and Yunfeng Lu. Synthesis of quaternary semiconductor nanocrystals with tunable band gaps. Chem. Mater., 2009, 21, 2489-2493

 

    • Daocheng Pan, Ding Weng, Xiaolei Wang, Qiangfeng Xiao, Wei Chen, Chuanlai Xu*, Zhengzhong Yang, Yunfeng Lu. Alloyed Semiconductor Nanocrystals with Broad Tunable Band Gaps. Chemical Communications, 2009, 4221- 4223.

 

    • Nan Zhao, Wei Ma, Zhimin Cui, Weiguo Song, Chuanlai Xu* and Mingyuan Gao. Polyhedral maghemite nanocrystals prepared by a flame synthetic method: preparations, characterizations, and catalytic properties. ACS Nano, 2009, 3, 1775-1780.

 

    • Chunhui Yang, Jingjie Du, Qian Peng, Ruirui Qiao, Wei Chen, Chuanlai Xu*, Zhigang Shuai, and Mingyuan Gao. Polyaniline/Fe3O4 nanoparticle composite: synthesis and reaction mechanism. Journal of Physical Chemistry B, 2009, 113: 5052-5058.

 

    • Libing Wang, Yingyue Zhu, Yuan Jiang, Ruirui Qiao, Shuifang Zhu, Wei Chen, and Chuanlai Xu*. Effects of quantum dots in polymerase chain reaction. Journal of Physical Chemistry B, 2009, 113, 7637–7641.

 

    • HuiLing Xie, LiQiang Liu, ChuanLai Xu*. Development and validation of an immunochromatographic assay for rapid multi-residues detection of cephems in milk. Analytica Chimica Acta. 2009, 634(1): 129-133.

 

    • Yuan Yuan, Chuanlai Xu*, and Chifang Peng. Analytical methods for the detection of corticosteroids-residues in animal-derived foodstuffs. Critical Reviews in Analytical Chemistry, 2008, 38: 227–241.

 

  • Xiaolei Hao, Hua Kuang, Yali Li, Yuan Yuan, Chifang Peng, Wei Chen, Libing Wang and Chuanlai Xu*. Development of an enzyme-linked immunosorbent assay for the α-cyano pyrethroids multi-residue in tai lake water. Journal of Agricultural and Food Chemistry, 2009, 57: 3033-3039.
 
 

2、专著
b1 b2 b3
 
 

3、授权专利
基于荧光量子点编码二氧化硅球进行多种转基因植物的检测方法 ZL 201010604671.0
一种金纳米管材料的制备方法及应用 ZL 201010597233.6
一种运用PCR-DHPLC检测沙门氏菌的方法 ZL 201010204906.7
一种电化学传感器对微量赭曲霉毒素A进行检测的方法 ZL 200910213207.6
一种基于金纳米棒端面自组装检测微囊藻毒素-LR的方法 ZL 200910035793.X
一种侧面组装的金纳米棒标记抗体定量检测氨苄青霉素的方法 ZL 200910035792.5
一种快速检测西布曲明的胶体金层析试纸条及制备方法 ZL 200910030401.0
一种量子点标记的间接竞争荧光免疫检测糖皮质激素多残留的方法 ZL 200810123524.4
一种量子点标记的间接竞争荧光免疫检测双氟米松的方法 ZL 200810123523.X
一种量子点标记的间接竞争荧光免疫检测倍他米松的方法 ZL 200810123522.5
一种量子点标记的间接竞争荧光免疫检测地塞米松的方法 ZL 200810123521.0
一种地西泮胶体金法检测试纸及制备方法 ZL 200810022250.X
一种微囊藻毒素-LR的免疫荧光猝灭检测方法 ZL 200810022245.9
一种通用型毒素纸质检测传感器的制备及应用 ZL 200910183680.4
一种适用于硝西泮残留分析的酶联免疫检测试剂盒 ZL 200810022160.0
一种运用动态光散射高灵敏检测微囊藻毒素的方法 ZL 200810155548.8
一种全氟辛酸的酶联免疫检测方法 ZL 200810234848.5
一种适用于盐酸西布曲明的免疫原合成方法 ZL 200810234852.1
一种拟除虫菊酯类药物群选性免疫亲和层析柱的制备方法 ZL 200910222578.0
石榴状磁性纳米粒子聚集体的制备及其在DNA分离纯化中的应用 ZL 201010101763.7
一种鱼过敏原标准物的制备方法 ZL 201010597749.0
一种高稳定性和功能化的金纳米粒子的制备方法 ZL 201010286955.X
一种具有表面增强拉曼活性的自组装材料的制备方法 ZL 201010605799.9
一种基于聚合酶链反应的金纳米棒可控自组装方法 ZL 201010604931.4
一种3-甲基-喹啉-2-羧酸的免疫荧光猝灭检测方法 ZL 200810022033.0
一种基于金磁纳米粒子的载药平台的构建与应用 ZL 200910232340.6
一种柠檬黄人工抗原的合成方法 ZL 200910031725.6
一种苏丹红II人工抗原的合成方法 ZL 200910031726.0
一种荧光量子点编码聚己内酯微球的制备方法 ZL 200910264974.X
一种金纳米粒子比色法快速检测奶粉中三聚氰胺含量的方法 ZL 201010196970.5
聚丙烯酸包覆四氧化三铁磁性纳米粒子的制备及其应用 Zl 200910182031.2
沉淀-氧化法制备葡聚糖四氧化三铁磁性纳米粒子及其应用 ZL 200910181247.7
一种临床磁共振成像检测庆大霉素的方法
ZL 200910027067.3
一种三聚氰胺人工抗原的合成方法
ZL 200810234130.6
一种具有氨基糖苷类药物多抗原决定簇人工抗原的合成方法
ZL 200810123016.6
一种4-氨基丁酸缩合菊酸半抗原的合成方法
ZL 200810019046.2
一种1-氨基乙内酰脲人工抗原的制备方法
ZL 200810019047.7
一种氨基糖苷类药物通用人工抗原的合成方法
ZL 200810123015.1
一种同时检测19中喹诺酮类药物的HPLC-ESI-MS/MS测定方法
ZL 200810022357.4
一种邻苯二甲酸二辛酯人工抗原的制备方法
ZL 200810022244.4
一种3-甲基-喹啉-2-羧酸的免疫磁珠检测方法 ZL 200710134517.X
一种b-内酰胺类药物通用人工抗原的合成方法 ZL 200810123017.0
一种β-内酰胺类药物通用人工抗原的合成方法 ZL 200710134518.4
一种地西泮人工抗原的制备方法
ZL 200710135000.2
一种氨基脲的衍生物氨基脲缩对醛基苯甲酸的合成方法
ZL 200710022542.9
一种3-甲基-喹啉-2-羧酸的制备方法
ZL 200710019665.7
一种二甲氧基磷酸酯类农药通用半抗原的合成方法
ZL 200710134520.1
一种间苯氧基苯甲氰丁二酸酯的合成方法
ZL 200710135301.5
甲羟孕酮醋酸酯特异性抗体的制备及该抗体用于同源或异源酶联免疫分析的方法 Zl 200710022047.8
一种硝西泮人工抗原的制备方法 ZL 200710022543.3
一种地赛米松人工抗原的制备方法 ZL 200710135242.1
一种双氟米松人工抗原的制备方法
ZL 200710135244.0
一种喹诺酮类抗生素多簇抗原的合成方法
ZL 200710134500.4
一种微生物青贮饲料添加剂及其制备方法
ZL 02112909.6
一种猪用生长激素脂质体及其制备方法
ZL 02112910.X
 

 

4、重大奖励
 
荣获省部级科技进步一等奖2项、二等奖7项;
2007、2009年度分别荣获国家科技进步二等奖2项.
 
 
 

 

5、国际交流
学术交流内容
组织单位
时间
提交研究成果情况
承担情况
Invited lecture
Moscow state university
2007.12
Immunochromatographic strip assay for screening chemical residues in animal foods
大会发言
The 1ST International Chester Food Science and Technology conference (ICFST), Austria
The University of Chester
2007.4
Determination of β lactoglobulin in milk by ELISA
大会发言
ⅧTH International conference on agri-food antibodies, England
The Society for Food and Agricultural Immunology
2005.9
Biomarkers of nitrofurazone use in animal derived food products
大会发言
The 15th international symposium on bioluminescence and chemiluminescence
International Society for Bioluminescence & Chemiluminescence (ISBC)
2008.5
Determination of beta-methasone residues in chicken tissue by fluorescence-linked immunosorbent assay with quantum dots.
大会发言
The 45th Congress of the European Societies of Toxicology
European Societies of Toxicology
2008.10
Development of the ELISA for detection of microcystin by using magnetic nanometer particle enrichment antibody.
大会发言
The Xth ICAFA Conference
University of Chester
2009.9
Pesticide detection using ELISA systems.
大会发言
 

 

6、成果转化
 
 
 

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详情请点击招生目录

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